Tamoxifen
- Generic Nolvadex is used for:
Treating breast
cancer that has spread to other sites in the body. It is also
used along with other medicines to treat other types of breast
cancer. It is used in women who are at high risk for breast cancer
and in women with DCIS (after surgery and radiation) to decrease
the risk of developing breast cancer. It may also be used for
other conditions as determined by your doctor.
Tamoxifen
- Generic Nolvadex is an antiestrogen. It works by blocking the
effect of estrogen on certain tumors. This may prevent the growth
of tumors that are activated by estrogen.
Common uses
This medicine
(Nolvadex - Tamoxifen) is an anti-estrogen used to treat or prevent
breast cancer. It may also be used to treat other conditions as
determined by your doctor.Tamoxifen is an antiestrogen (blocks
the effect of estrogen on tissue). The precise mechanism of its
action is unknown, but one possible mechanism is that it binds
and blocks estrogen receptors on the surface of cells, preventing
estrogens from binding and activating the cell. It is used in
patients for treating and preventing breast cancer. Controversy
currently exists as to which breast cancer patients will benefit
from this treatment.
Before using
Warning: tamoxifen
rarely may cause serious (possibly fatal) side effects. These
include cancer of the uterus (endometrial cancer and uterine sarcoma),
as well as strokes and blood clots in the lung (pulmonary emboli).
Tell your doctor immediately if you develop: abnormal vaginal
bleeding, irregular or abnormal menstrual periods, groin pain
or pressure, chest pain, trouble breathing, one-sided weakness.
If you are taking this medicine (Nolvadex - Tamoxifen) for prevention
of breast cancer (those with ductal carcinoma in situ-dcis, or
those at high risk for breast cancer) you should discuss with
your doctor the risks of treatment as compared to the benefits.
However, if you are taking tamoxifen for treatment of breast cancer,
the proven benefits clearly are greater than the risk of side
effects. Consult your doctor or pharmacist for more details. Do
not take this medicine (Nolvadex - Tamoxifen) if you are also
taking letrozole. Additional monitoring of your dose or condition
may be needed if you are taking fluorouracil, mitomycin or rifampin.
Inform your doctor of any other medical conditions, allergies,
pregnancy, or breast-feeding. Contact your doctor or pharmacist
if you have any questions or concerns about taking this medicine
(Nolvadex - Tamoxifen).
PRESCRIBED
FOR:
Tamoxifen
is used for the treatment of invasive breast cancer, the most
common type of breast cancer, following surgery and/or radiation
and for preventing invasive breast cancer in women at high risk
for developing it. Tamoxifen also is used for the treatment of
women following surgery and radiation for a less common type of
breast cancer called ductal carcinoma in situ (DCIS or intraductal
carcinoma). Women who have had ductal carcinoma in situ are at
high risk for developing invasive breast cancer at a later date,
and tamoxifen prevents development of the invasive cancer in almost
half of the women during the first five years of treatment. Occasionally,
tamoxifen is used to stimulate ovulation.
Directions
Follow the
directions for using this medicine (Nolvadex - Tamoxifen) provided
by your doctor. This medicine (Nolvadex - Tamoxifen) may come
with a patient information leaflet. Ask your doctor, nurse, or
pharmacist any questions that you may have about this medicine
(Nolvadex - Tamoxifen). This medicine (Nolvadex - Tamoxifen) may
be taken on an empty stomach or with food. Store this medicine
(Nolvadex - Tamoxifen) at room temperature in a tightly-closed
container, away from heat and light. If you miss a dose of this
medicine (Nolvadex - Tamoxifen), take it as soon as possible.
If it is almost time for your next dose, skip the missed dose
and go back to your regular dosing schedule. Do not take 2 doses
at once.
Cautions
A barrier
or non-hormonal form of birth control is recommended for pre-menopausal
women while taking this medicine (Nolvadex - Tamoxifen). Keep
all doctor and laboratory appointments (e.g., yearly pelvic/gynecology
exams) while you are using this medicine (Nolvadex - Tamoxifen).
This medicine (Nolvadex - Tamoxifen) has been shown to cause harm
to the human fetus. If you plan on becoming pregnant, discuss
with your doctor the benefits and risks of using this medicine
(Nolvadex - Tamoxifen) during pregnancy. It is unknown if this
drug is excreted in breast milk. Do not breast-feed while taking
this medicine (Nolvadex - Tamoxifen).
Possible
side effects
Side effects,
that may go away during treatment, include hot flashes, vaginal
discharge, irregular or lighter menstrual cycles, weight loss,
or diarrhea. If they continue or are bothersome, check with your
doctor. Check with your doctor as soon as possible if you experience
vaginal bleeding, unexplained sore throat or fever, or unusual
bleeding or bruising. If you notice other effects not listed above,
contact your doctor, nurse, or pharmacist.
If you take
too much
If overdose
is suspected, contact your local poison control center or emergency
room immediately. Symptoms of overdose may include shakiness,
dizziness, and irregular heartbeat.
Additional
information
Do not share
this medicine (Nolvadex - Tamoxifen) with others for whom it was
not prescribed. Do not use this medicine (Nolvadex - Tamoxifen)
for other health conditions. Keep this medicine (Nolvadex - Tamoxifen)
out of the reach of children. If using this medicine (Nolvadex
- Tamoxifen) for an extended period of time, obtain refills before
your supply runs out.
Drug interactions
Drug interactions
can result in unwanted side effects or prevent a medicine (Nolvadex
- Tamoxifen) from doing its job. Some medicine (Nolvadex - Tamoxifen)s
or medical conditions may interact with this medicine (Nolvadex
- Tamoxifen). Inform your doctor or pharmacist of all prescription
and over-the-counter medicine (Nolvadex - Tamoxifen) that you
are taking.Tamoxifen can cause abnormalities of liver tests and
other blood tests, and patients taking it should keep appointments
for blood work to monitor for these side effects. Patients should
report any suspected side effects immediately, especially bleeding
and yellowing of the skin.
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